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National Center for Biotechnology Information

Building From MEDLINE

MEDLINE indexes 3300 different journals a month

Sequence containing articles routed to NCBI Backbone

Send citations to collaborators.

Is Sequence a public direct submission?

Is GenBank: Update citation, check entry, release

Is Collaborator: Inform collaborator

Is Sequence a GenBank Hold Until Published?

Update citation and release.

Enter Sequence from article.

Release as NCBI Backbone Entry.

Map citations from other databases to a common reference.

Provide important content linkage for Sequence data.

National Center for Biotechnology Information

Building an Integrated Sequence Resource.

Convert Disparate Data Sources to a Common Representation

NCBI Backbone Nucleotide and Protein

GenBank Direct Submissions Nucleotide

EMBL Nucleotide

DDBJ Nucleotide

PIR Protein

SWISSPROT Protein

PRF Protein

PDB (Protein)

USPTO Nucleotide and Protein

dbEST Nucleotide

*Maintain Live, Real Time View

*Provide a Stable, Uniform Identifier

Map to Non-sequence Data

Citations To MEDLINE

*Organisms To Taxon

*Gene Symbols to Maps

National Center for Biotechnology Information

Providing an Integrated Sequence Resource

Different forms for different purposes

NCBI GenBank

Nucleotide only

NCBI Backbone

GenBank Direct Submissions

EMBL

DDBJ

USPTO

Familiar "flatfile" format

NCBI Sequences

Nucleotide and Protein from all sources

ASN.1 format

ASCII indexes

Entrez

Nucleotide and Protein from all sources

MEDLINE references

Huffman compressed ASN.1 format

Binary hierarchical indexes

End user retrieveal system

Retrieval library source code in public domain

Network Entrez

Entrez on the internet

National Center for Biotechnology Information

Providing an Integrated Sequence Resource

Retrieve Server

Email entry retrieval

Blast Server

Email

Client/Server

dbEST Server

FTP Server

ASN.1

GenBank Flatfile